个人简介：

孔庆然，温州医科大学第三层次引进人才，检验医学院、生命科学学院，副教授、硕士生导师，生物信息教研室主任。研究方向为哺乳动物早期胚胎发育机制研究，致力于采用低样本高通量检测和生物信息分析解析技术解析细胞代谢与表观遗传修饰互作对哺乳动物早期胚胎发育关键生物学事件的调控作用。近年来，主持国家自然科学基金等国家级课题3项；以通讯作者和第一作者身份在Cell Discovery，JBC，FASEB J，CDDISCO，BOR等杂志发表SCI论文30余篇；获得授权发明专利5项，其中国际专利1项。

近年来发表代表性论文如下（*通讯作者）：

1. Jingyu Li, Jiaming Zhang, Weibo Hou, Xu Yang, Xiaoyu Liu, Yan Zhang, Meiling Gao, Ming Zong, Zhixiong Dong, Zhonghua Liu, Jingling Shen, Weitao Cong, Chunming Ding, Shaorong Gao*, Guoning Huang*, and Qingran Kong*. 2022. Metabolic control of histone acetylation for precise and timely regulation of minor ZGA in early mammalian embryos. Cell Discovery. 8: 96. (IF：38.079)

2. Jiaming Zhang; Weibo Hou; Jiawei Du; Ming Zong; Kailun Zheng; Weijia Wang; Jiaqiang Wang; Heng Zhang; Yanshuang Mu; Zhi Yin; Chunming Ding; Qingyuan Sun*; Zhonghua Liu*; Qingran Kong*. 2020. Argonaute 2 is a key regulator of maternal mRNA degradation in mouse early embryos. Cell Death Discovery. 6(133). (IF：7.109)

3. Xiaolei Zhang, Jiaming Zhang, Kailun Zheng, Heng Zhang, Xixiang Pei, Zhi Yin, Duancheng Wen, Qingran Kong*. 2019. Long noncoding RNAs sustain high expression of exogenous Oct4 by sponging miRNA during reprogramming. Journal of Biological Chemistry. 294(47): 17863-17874.（IF：5.486）

4. Qingran Kong, Xu Yang, Heng Zhang, Shichao Liu, Jianchao Zhao, Jiaming Zhang, Xiaogang Weng, Junxue Jin and Zhonghua Liu*. 2019. Lineage specification and pluripotency revealed by transcriptome analysis from oocyte to blastocyst in pig. FASEB J. 34(3): 1-15.（IF：5.834）

5. Qingran Kong, Laura A. Banaszynski, Fuqiang Geng, Xiaolei Zhang, Jiaming Zhang, Heng Zhang, Claire Liane O’Neill, Gianpiero D. Palermo1, C. David Allis, Shahin Rafii, Zev Rosenwaks, Duancheng Wen*. 2018. Histone variant H3.3-mediated chromatin remodeling is essential for paternal genome activation in mouse preimplantation embryos. Journal of Biological Chemistry. 293(10):3829-3838. (IF：5.486)