个人情况

吴文鹤，博士，硕导，副教授，美国纽约阿尔伯特·爱因斯坦医学院博士后。现任温州医科大学检验医学院（生命科学学院）基础检验系副主任、检验医师培养发展中心主任。多年来一直从事肥胖、衰老、代谢性相关疾病的机制研究和肠道微生物的检测，先后主持完成国家自然科学基金青年科学基金项目和面上项目各1项，主持在研省自然基金项目、省医药卫生科技计划项目和市级科研项目等；相关成果荣获第六届全国中青年检验医学学术会议优秀论文特等奖、罗氏诊断中国医学及生命科学教育研究基金等荣誉，共发表相关论文20余篇，授权国家发明专利1项；指导学生完成省级课题3项和校课题2项，在研省级课题1 项，并获得全国大学生创业大赛创业实践挑战赛金奖和全国大学生课外学术科技作品竞赛特等奖等荣誉。

研究方向：

肥胖、衰老、代谢性相关疾病的机制研究和肠道微生物的检测

代表性论文:

1. Deng Y, Yi X, Gong Y Zhou L, Xie D, Wang J, Liu Z, Zhang Y, Wu W*. Palmitic acid induces nDNA release to cytosol and promotes microglial M1 polarization via cGAS-STING signaling pathway. Biochim Biophys Acta Mol Cell Res, 2023, 1870(1): 119385.

2. Gong Y, Huang Q, Deng Y, Zhou L, Yi X, Zhu J, Wu W*. Analysis of cf-mtDNA and cf-nDNA fragment size distribution using different isolation methods in BV-2 cell supernatant of starvation-induced autophagy. Biochim Biophys Acta Mol Cell Res 2021,1869(1):119147.

3. Wang Z, Wu W, Kim MS, Cai D. GnRH pulse frequency and irregularity play a role in male aging. Nat Aging 2021,1:904-918.

4. Rong M, Li J, Hu J, Chen A, Wu W*, Lyu J. A highly sensitive and colorimetric biosensor based on magnetic nano-DNAzyme for detection of lead (II) ion in real water samples. Journal of Chemical Technology & Biotechnology 2018,93(11):3254-3263.

5. Han C, Wu W, Ale A, Kim MS, Cai D. Central Leptin and Tumor Necrosis Factor-alpha (TNFalpha) in Diurnal Control of Blood Pressure and Hypertension. J Biol Chem 2016,291(29):15131-15142.

6. Kim MS, Yan J, Wu W, Zhang G, Zhang Y, Cai D. Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis. Nat Immunol 2015,16(5):525-533.

7. Wu W, Li J, Pan D, Li J, Song S, Rong M, Li Z, Gao J, Lyu J. Gold nanoparticle-based enzyme-linked antibody-aptamer sandwich assay for detection of Salmonella

Typhimurium. ACS Appl Mater Interfaces 2014,6(19):16974-16981.

8. Wu W, Li M, Wang Y, Ouyang H, Wang L, Li C, Cao Y, Meng Q, Lyu J. Aptasensors for rapid detection of Escherichia coli O157:H7 and Salmonella typhimurium. Nanoscale Res Lett 2012,7(658.

9. Su S, Wu W, Gao J, Lyu J, Fan C. Nanomaterials-based sensors for applications in environmental monitoring. J Mater Chem 2012,22(35):18101-18110.

10. Wu W, Hu H, Li F, Wang L, Gao J, Lu J, Fan C. A graphene oxide-based nano-beacon for DNA phosphorylation analysis. Chem Commun (Camb) 2011,47(4):1201-1203.

论著、专利等学术成果:

1.分子生物学（第2版），高等教育出版社，2021，参编

2.检验与临床诊断：分子诊断学分册，人民军医出版社， 2010，参编

3.吕建新，陈勇，吴文鹤。基于适配体的光化学生物传感器及其检测靶物质的方法，2011.7.13，中国，ZL20091016976.X