李红智 教授，硕士，硕士生导师 E-mail: lhz@wzmc.edu.cn

个人简介：

李红智，硕士，教授，硕导。曾在美国德州大学等做访问学者达3年多。中华医学会医学细胞生物学分会委员，浙江省遗传学会理事，中国细胞生物学学会医学细胞生物学分会委员，浙江省细胞生物学学会常务理事，中国转化医学联盟理事，浙江省新世纪151人才工程培养人选。以第一作者或通讯作者，在Nucleic Acids Res、Free Rad Bio Med、BBA - Mol Basis Dis、J Immunother、Front Onco、Am J Cancer Res、Mol Med等高水平杂志发表SCI论文。累计发表学术论文60多篇。曾主编或副主编《医学遗传学》、《医学细胞生物学》教材。

研究方向：

1、肿瘤基因治疗，主要是乳腺癌等CAR-T细胞治疗。

2、线粒体病基因治疗，主要是神经变性疾病的线粒体缺陷治疗。

3、遗传病基因诊断，涉及多种单基因病及复杂多基因病。

主持的国家级科研项目：

1、国家自然科学基金面上项目“酵母NDI1的重组腺相关病毒对线粒体复合体I功能缺陷所致散发性帕金森病的基因治疗研究（81971291）”，直接费用55万元，2020年01月至2023年12月。

2、国家自然科学基金面上项目“采用新型抗Her2嵌合抗原受体T细胞联用免疫抑制通路阻遏来克服乳腺癌赫赛汀耐药的研究（81572980）”，直接费用57万元， 2016年01月至 2019年 12月。

代表性论文 (^*通讯作者，^#第一作者)：

(1) Hongzhi Li^*#, Bohao Sun^#, Yuting Huang, Jing Zhang, Xuejing Xu, Yuqi Shen, Zhuo Chen, Jifeng Yang, Luxi Shen, Yongwu Hu, Haihua Gu^*. Gene therapy of yeast NDI1 on mitochondrial complex Ⅰ dysfunction in rotenone-induced Parkinson's disease models in vitro and vivo. Molecular Medicine, 2022, 28:29

(2) Panyuan Li, Lingcong Yang, Tong Li, Shufang Bin, Bohao Sun, Yuting Huang, Kaiyan Yang, Daming Shan^*, Haihua Gu^*, Hongzhi Li^*.The third generation anti-HER2 chimeric antigen receptor mouse T cells alone or together with anti-PD1 antibody inhibits the growth of mouse breast tumor cells expressing HER2 in vitro and in immune competent mice. Front. Oncol. 2020 Jul, 10:1143

(3) Hongzhi Li^#*, Weihua Yuan^#, Shufang Bin, Guang Wu, Panyuan Li, Min Liu, Jifeng Yang, Xiang Li, Kaiyan Yang, Haihua Gu^*.Overcome trastuzumab resistance of breast cancer using anti-HER2 chimeric antigen receptor T cells and PD1 blockade. American Journal of Cancer Research, 2020,10(2): 688-703

(4) Hongzhi Li^*, Luxi Shen, Peiqing Hu, Rong Huang, Ying Cao, Janice Deng, Weihua Yuan, Danhui Liu, Jifeng Yang, Haihua Gu^*, Yidong Bai^*. Aging-associated mitochondrial DNA mutations alter oxidative phosphorylation machinery and cause mitochondrial dysfunctions. BBA - Molecular Basis of Disease, 2017,1863 (9):2266-2273.

(5) Chaoyan Wang, Wangxiong Hu, Luxi Shen, Ruiyan Dou, Shengke Zhao, Daming Shan, Kang Yu, Rong Huang, and Hongzhi Li^*. Adoptive antitumor immunotherapy in vitro and in vivo using genetically activated erbB2-specific T cells. Journal of Immunotherapy, 2014, 37(7): 351-359.

(6) Hongzhi Li ^#, Lokendra Kumar Sharma#, Youfen Li#, Peiqing Hu, Abimbola Idowu, Danhui Liu, Jianxin Lu, Yidong Bai^*. Comparative bioenergetic study of neuronal and muscle mitochondria during aging. Free Radic Biol Med, 2013, 63:30-40.

(7) Youfen Li^#, Hong-Zhi Li^#, Peiqing Hu, Janice Deng, Mohammad Mehdi Banoei, Lokendra Kumar Sharmaand, Yidong Bai^*. Generation and bioenergetic analysis of cybrids containing mitochondrial DNA from mouse skeletal muscle during aging. Nucleic Acids Research, 2010, 38(6): 1913–1921.