个人简介：
申志发，加拿大蒙特利尔大学博士、研究员，美国NIH癌症研究中心（NCI at Frederick）博后，温州医科大学研究员（PI），博士生导师；浙江省 “钱江学者”特聘教授；在肿瘤转移分子机制、功能核酸探针、核酸纳米器件、化学生物传感及细胞内关键生物分子原位成像和癌症的诊断与靶向治疗等领域发表SCI论文40多篇，其中Genes Dev 、Nat Commun、J Am Chem Soc、Angew Chem Int Ed或其它中科院JCR一区期刊SCI论文有20余篇； CHEM ENG J. Mol. Bio. Cell 、Anal. Chem. Biosens Bioelectron等学术期刊审稿专家；研究生《医学分子生物学》、《现代生物学技术与进展》课程负责人，博生、硕士、留学生《分子生物学》专业课主讲教授，本科生«专业外语»讲授等。
研究方向
肿瘤转移分子机制与靶向治疗。在该领域，应用活细胞单分子成像、核酸适配体筛选、核酸纳米器件组装等核心技术，开展肿瘤转移进程中STAT3 mRNA胞内定位翻译机制的角色，针对特定靶点进行早期诊断以及靶向治疗等研究。
主持的科研项目：
1.浙江省自然科学基金重点项目，STAT3 mRNA胞突定位翻译机制及其对肝癌转移作用的研究，LZ22H160007，2022-01-01 至 2024-12-31，30万，主持。
2.温州医科大学重大横向研究项目，肝癌/结直肠癌早期诊断试剂盒研发与孵育，KJHX2120，2021-07至2023-06， 200万，主持。
近两年代表性论文:
1.Bo wen Liu, Xiang yun Wang, Jin ling Cao, Lu lu Chen, Yilei Wang, Bing-qian Zhao, Jia Zhou，Zhi-fa Shen * TDP-43 upregulates lipid metabolism modulator ABHD2 to suppress apoptosis in hepatocellular carcinoma. Communications Biology. 2022,5:816 一区/IF6.548
2.XuemeiHu,JingZhang,QuanYuan,QiaoGuo,ZhifaShen*.StudyonSgc8Aptamer-mediatedNucleicAcidNanomaterial-doxorubicinComplexforTumorTargetedTherapy.EurJPharmBiopharm.2023.EJPB,13965.一区/IF5.589.
3.Xiaoliang Zhao, Jie Yang, Jing Zhang, Xiangyun Wang, Lulu Chen, Chao Zhang, Zhifa Shen *. Inhibitory effect of aptamer-carbon dot nanomaterial-siRNA complex on the metastasis of hepatocellular carcinoma cells by interfering with FMRP. Eur J Pharm Biopharm.2022,174:47-55.一区/IF5.589.
4.Guoqiao Huang , Hongyin Zhou, Qi Xiang , Jing Zhang , Xuemei Hu , Ruize Cheng , Linwen Lan , Yuzhe Wang , Zhifa Shen * Exponential and efficient target-catalyst rolling circle amplification for label-free and ultrasensitive fluorescent detection of miR-21 and p53 gene. Analytica Chimica Acta,1221 (2022) 340132一区/IF6.889.
5.Shu lin Yang, Huan qin Guan, Hong bao Yang, Yao Chen, Xiao ying Huang, Lei Chen, Zhi fa Shen* and Liang xing Wang* The expression and biologicaleffect of NR2F6 in non-small cell lung cancer. Frontiers in Oncology, 10.3389/fonc.2022.940234. 二区/IF6.18.
6.Jing Zhang , Qi Xiang , Xuemei Hu , Guoqiao Huang , Quan Yuan , Qiufeng Song , Yinghao Cheng , Chan Li , Chang Xue , Zhifa Shen * Triple-hairpin mediated feedback system based on rolling circle amplification for enhanced imaging and detection of intracellular microRNA. Sensors and Actuators B-Chemical. 375 (2023) 132896一区/IF9.589.
7.Guoqiao Huang, Jing Zhang, Yinghao Cheng, Chan Li, Qiufeng Song, Chang Xue , Zai-sheng Wu, Zhifa Shen* Target-induced multiple palindrome-mediated strand displacement amplification of Scarecrow-shaped DNA nanoprobe for ultrasensitive detection of MicroRNA Sensors and Actuators B-Chemical. 376 (2023) 133003一区/IF9.589..
8.Ning Wang, Chang Yu, Tingting Xu, Dan Yao, Lingye Zhu, Zhifa Shen* and Xiaoying Huang*Self-assembly of DNA nanostructure containing cell-specific aptamer as a precise drug delivery system for cancer therapy in non-small cell lung cancer. Journal of Nanobiotechnology (2022) 20:486. 一区/IF11.509.
9.Cheng Zheng , Xiangyun Wang, Shujuan Sun, Xuemei Hu and Zhifa Shen* Hairpin allosteric molecular beacons-based cascaded amplification for effective detection of lung cancer-associated microRNA. Talanta, 2022， 244:123412. doi: 10.1016/j.talanta.2022.123412. IF 6.13 (JCR一区)
