简介
申志发，加拿大蒙特利尔大学博士、研究员，美国NIH癌症研究中心（NCI at Frederick）博后，温州医科大学研究员（PI），博士生导师；温州市“580海外精英引进人才”，浙江省 “钱江学者”特聘教授；在肿瘤转移分子机制、功能核酸探针、核酸纳米器件、化学生物传感及细胞内关键生物分子原位成像和癌症的诊断与靶向治疗等领域发表SCI论文40多篇，其中Genes Dev 、Nat Commun、J Am Chem Soc、Angew Chem Int Ed或其它中科院JCR一区期刊SCI论文有20余篇； CHEM ENG J. Mol. Bio. Cell 、Anal. Chem. Biosens Bioelectron等学术期刊审稿专家；研究生《医学分子生物学》、《现代生物学技术与进展》课程负责人。博生、硕士、留学生专业课程主讲教授、本科生«专业外语»专题设计等。
近年来，主持或负责包括Canadian Institutes of Health Research (CIHR)1项、国家自然科学基金5项、浙江省自然科学基金重点项目2项及面上项目5项在内的共15项国家及省部级课题，在研科研经费500余万元；
招生专业：
申志发+ 医学技术2人(学硕)+临床检验诊断学1人(学硕)+临床检验诊断学3人(专硕)
近一年代表论文(第一作者均为本课题组硕士生)
1. Xuemei Hu, Jing Zhang, Quan Yuan, Qiao Guo, Zhifa Shen *. Study on Sgc8 Aptamer-mediated Nucleic Acid Nanomaterial-doxorubicin Complex for Tumor Targeted Therapy. Eur J Pharm Biopharm.2023.EJPB,13965.一区/IF5.589.
2. Jing Zhang , Qi Xiang , Xuemei Hu , Guoqiao Huang , Quan Yuan , Qiufeng Song , Yinghao Cheng , Chan Li , Chang Xue , Zhifa Shen * Triple-hairpin mediated feedback system based on rolling circle amplification for enhanced imaging and detection of intracellular microRNA. Sensors and Actuators B-Chemical. 375 (2023) 132896一区/IF9.589.
3. Guoqiao Huang, Jing Zhang, Yinghao Cheng, Chan Li, Qiufeng Song, Chang Xue , Zai-sheng Wu, Zhifa Shen* Target-induced multiple palindrome-mediated strand displacement amplification of Scarecrow-shaped DNA nanoprobe for ultrasensitive detection of MicroRNA Sensors and Actuators B-Chemical. 376 (2023) 133003一区/IF9.589..
4. Bo wen Liu, Xiang yun Wang, Jin ling Cao, Lu lu Chen, Yilei Wang, Bing-qian Zhao, Jia Zhou，Zhi-fa Shen * TDP-43 upregulates lipid metabolism modulator ABHD2 to suppress apoptosis in hepatocellular carcinoma. Communications Biology. 2022,5:816 一区/IF6.548
5. Guoqiao Huang , Hongyin Zhou, Qi Xiang , Jing Zhang , Xuemei Hu , Ruize Cheng , Linwen Lan , Yuzhe Wang , Zhifa Shen * Exponential and efficient target-catalyst rolling circle amplification for label-free and ultrasensitive fluorescent detection of miR-21 and p53 gene. Analytica Chimica Acta,1221 (2022) 340132一区/IF6.889.
