Raman spectroscopy for noninvasive diagnosis and precision medicine in gastrointestinal diseases
Dr. XiaohongBi is an Assistant Professor in the Institute of Molecular Medicine at theUniversity of Texas Health Science Center at Houston. Dr. Bi develops opticaltechniques for disease diagnosis with a special interest in bone andgastrointestinal research. She received her B.S. in biochemistry from NanjingUniversity in China, M.S. and Ph.D. in chemistry from Rutgers University in NewJersey, USA. Dr. Bi worked as a research assistant professor of BiomedicalEngineering in Vanderbilt University from 2008 to 2012. In 2012, Dr. Bi joinedthe faculty in the University of Texas. She has received a prestigious careerdevelopment award from the National Institute of Health, research grants fromAmerican Society of Colon and Rectal Surgeons (ASCRS), the Broad MedicalResearch Program at Crohn’s & Colitis Foundation of America (CCFA), andseveral institutional grant supports. She has authored over 30 peer-reviewedpublications, 2 book chapters, and 2 US patents in optical engineering.
Ramanscattering is sensitive to molecular structure and composition in the tissue.Previous studies have identified spectral signatures from various biomoleculessuch as protein, lipid, nucleic acid, proteoglycan, and hydroxyapatite.Diagnostic information could be obtained by analyzing disease-associatedchanges in these biomolecules in the tissue. Development of optical fibersenabled in vivo Raman measurements in real time and thus potential translationto clinical settings. Our laboratory has developed endoscopic Raman techniqueand applied it to characterize alterations in tissue composition during thedevelopment of inflammatory bowel disease. I will present our recent progressin the management of gastrointestinal inflammation that covers characterizationof diseased tissue in the laboratory and implementation of endoscopic Raman toclinical studies in vivo for improved diagnosis.