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吕建新 教授
2017-06-01 10:44  

吕建新  教授
教授,博士,博士生导师
电话:
E-mail: jxlu313@163.com

个人简介:

吕建新,医学博士,教授,博士生导师,现任杭州医学院院长,检验医学教育部重点实验室主任,浙江省医学遗传学重点实验室主任,教育部医学技术类专业教学指导委员会副主任委员。浙江省一流学科(A类)“医学技术”负责人、浙江省临床检验诊断技术重点科技创新团队负责人,全国高等医学院校医学检验专业校际协作副理事长。中国医师协会检验医师分会常务委员、线粒体疾病检验医学专家委员会主任委员,中国医药生物技术协会纳米生物技术分会常务委员,中国生物化学与分子生物学会理事。2009年被评为中国检验医学十大杰出贡献人物。

吕建新教授系中组部联系的高级专家,享受国务院政府特殊津贴,2013年入选国家百千万人才工程,并授予浙江省有突出贡献中青年专家,1997年入选浙江省“151人才工程”第一层次人才。主持国家“863”计划项目课题、国家重大科技(重大传染病)专项课题、国家自然科学基金项目等10余项。获浙江省科学技术奖一等奖2项,二等奖2项,三等奖4项;中华医学科技奖二等奖2项;浙江省优秀教学成果奖一等奖2项,二等奖1项。主编《临床分子生物学检验》、《分子诊断学》等教材和著作十余部,发表学术论文200余篇(其中SCI收录100余篇),获授权发明专利10余项。

研究方向:

主要从事分子生物学检验与分子诊断技术研究,重点研究领域为线粒体疾病(Leigh病、线粒体糖尿病等)、线粒体功能蛋白质的结构与功能(铁硫蛋白、转铁蛋白、呼吸链复合体等)、重大传染病的早期分子生物学检验诊断、生物传感器开发。

近三年论文:
1. Niacin Activates the PI3K/Akt Cascade via PKC- and EGFR-Transactivation-Dependent Pathways through Hydroxyl-Carboxylic Acid Receptor 2,PLOS ONE,2014,9
11,通讯作者

2. Iron inhibits Escherichia coli topoisomerase I activity by targeting the first two zinc-binding sites in the C-terminal domain,PROTEIN SCIENCE,20142311,通讯作者

3. Gold Nanoparticle-Based Enzyme-Linked Antibody-Aptamer Sandwich Assay for Detection of Salmonella Typhimurium,ACS APPLIED MATERIALS & INTERFACES,2014619,通讯作者

4. Glutamine synthetase plays a role in D-galactose-induced astrocyte aging in vitro and in vivo,EXPERIMENTAL GERONTOLOGY,201458 ,通讯作者

5. Exposure to high glutamate concentration activates aerobic glycolysis but inhibits ATP-linked respiration in cultured cortical astrocytes,CELL BIOCHEMISTRY AND FUNCTION,2014326,通讯作者

6. Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population,INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2014152,通讯作者

7. Elevated NKT cell levels in adults with severe chronic immune thrombocytopenia,EXPERIMENTAL AND THERAPEUTIC MEDICINE,201471,通讯作者

8. Graphene-based nanoprobes and a prototype optical biosensing platform,BIOSENSORS & BIOELECTRONICS,201350,通讯作者

9. Down-Regulating Overexpressed Human Lon in Cervical Cancer Suppresses Cell Proliferation and Bioenergetics,PLOS ONE,2013811,通讯作者

10. A novel heteroplasmic mitochondrial DNA mutation, A8890G, in a patient with juvenile-onset metabolic syndrome: A case report,MOLECULAR MEDICINE REPORTS,201384,通讯作者

11. Mitochondrial Common Deletion, a Potential Biomarker for Cancer Occurrence, Is Selected against in Cancer Background: A Meta-Analysis of 38 Studies,PLOS ONE,201387,通讯作者

12. The polymorphism in the let-7 targeted region of the Lin28 gene is associated with increased risk of type 2 diabetes mellitus,MOLECULAR AND CELLULAR ENDOCRINOLOGY ,20133751-2,通讯作者

13. Functional Investigation of NCI-H460-Inducible Myofibroblasts on the Chemoresistance to VP-16 with a Microfluidic 3D Co-Culture Device,PLOS ONE,20138(4),通讯作者

14. Competition of zinc ion for the [2Fe-2S] cluster binding site in the diabetes drug target protein mitoNEET,BIOMETALS,2012256,通讯作者

15. The clinical diagnostic significance of cerebrospinal fluid D-lactate for bacterial meningitis,CLINICA CHIMICA ACTA,2012,413( 19-20),通讯作者

16. Analysis of mitochondrial DNA variations in a Chinese family with spinocerebellar ataxia,JOURNAL OF CLINICAL NEUROSCIENCE,2012,19(1),通讯作者

17. Sargassum fusiforme polysaccharide activates nuclear factor kappa-B (NF-kappa B) and induces cytokine production via Toll-like receptors,CARBOHYDRATE POLYMERS,2,014,105,6

18. Ultrasensitive electrochemical DNA sensor based on the target induced structural switching and surface-initiated enzymatic polymerization,BIOSENSORS & BIOELECTRONICS,2014,55,6

19. Induction of adhesion molecule expression in co-culture of human bronchial epithelial cells and neutrophils suppressed by puerarin via down-regulating p38 mitogen-activated protein kinase and nuclear factor kappa B pathways, CHINESE JOURNAL OF INTEGRATIVE MEDICINE,2014,20(5),5

20. Iron and zinc binding activity of Escherichia coli topoisomerase I homolog YrdD,BIOMETALS,2014,27(2),6

21. Nanomaterial-Based Fluorescent DNA Analysis: A Comparative Study of the Quenching Effects of Graphene Oxide, Carbon Nanotubes, and Gold Nanoparticles,ADVANCED FUNCTIONAL MATERIALS,2013,23(33),4

22. A Graphene Oxide-Based Fluorescent Biosensor for the Analysis of Peptide-Receptor Interactions and Imaging in Somatostatin Receptor Subtype 2 Overexpressed Tumor Cells,ANALYTICAL CHEMISTRY,2013,85(16),5

23. Mixed protein-templated luminescent metal clusters (Au and Pt) for H2O2 sensing,NANOSCALE RESEARCH LETTERS,2013,8,4

24. The protective effect and underlying mechanism of metformin on neointima formation in fructose-induced insulin resistant rats,CARDIOVASCULAR DIABETOLOGY,201312,1

25. Nanomaterials-based sensors for applications in environmental monitoring,JOURNAL OF MATERIALS CHEMISTRY,201222 35,4

26. Physiology and Pathophysiology of Mitochondrial DNA,ADVANCES IN MITOCHONDRIAL MEDICINE,丛书2012 942 ,3

在研课题:
1. miR-486/3107
通过调节PTENFoxo1表达影响VLDL合成的研究,国家自然科学基金,31370795,2014-012017-12,80

2.水中铅、汞、镉的生物荧光检测技术和产品研发,国家高技术研究发展计划(863计划),2014AA06A514,2014-012016-12,37

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